CAREERS at QurAlis

About the Company

About the Company

QurAlis is specifically focused on discovering and developing new therapies for amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease. ALS is a devasting disease which causes rapid death of motor neurons leading to paralysis and an inability to speak and to breath, with an average life expectancy of only 3 years and an age of onset averaging at 55. Recent advances in DNA sequencing of patients show that ALS can be caused by mutations in over 20 different genes and is actually a combination of multiple different sub-forms of the disease. About half the genes involved in ALS are also involved in frontotemporal dementia (FTD). It is therefore unlikely that all ALS patients can be treated the same way.

 

The QurAlis strategy is to go for ALS one gene at a time. We do this by using a transformative system in which cells from ALS patients are used to model the disease in a dish to identify new drugs. Two of the founders of QurAlis, Harvard professors Kevin Eggan and Clifford Woolf have pioneered this technology for ALS resulting in the discovery of a potential new ALS drug, Ezogabine, which is now being tested in a phase 2 clinical trial. QurAlis has developed 3 programs which will bring new therapies to ALS patients.

 

QurAlis, together with its parent company Q-State, provides best-in-class R&D for:

  • Patient derived stem cell technology
  • Motor neuron drug discovery,
  • Motor neuron toxicity screening,
  • Mechanistic studies,
  • Model development and model validation.

 

Learn more at http://www.quralis.com

Open Positions

Research Associate, Stem Cell Neurobiology

Summary of Position

QurAlis is seeking a highly motivated Research Associate to support and execute it’s cutting edge discovery and screening efforts. The Research Associate will work closely with the QurAlis scientific and management teams to perform studies in a high quality and scientifically rigorous fashion.  

 

Responsibilities and Duties

  • Expands and maintains a variety of cell lines using exceptional sterile technique
  • Evaluates newly introduced cell lines for quality and potential contamination
  • Prepares cell lines for all-optical electrophysiology recordings, including lentiviral delivery of actuators and reporters
  • Develops phenotypic readouts using cell reporter reagents
  • Determines RNA and protein levels after gene or protein manipulations
  • Keeps accurate and up-to-date work logs
  • Orders and prepares media, nutrients, buffers, and reagents for cell culture
  • Maintains reagent and general lab supply inventory
  • Assists in maintenance of the cell culture facility and equipment
  • Assists in the generation and implementation of standard operating procedures
  • Other duties as assigned

 

Minimum Qualifications Required

  • A Bachelor’s degree in cell biology, biochemistry, neuroscience, or a related field
  • A minimum of two years of hands-on experience in mammalian tissue culture, preferably with stem cells and or neurons
  • Ability to work independently and in cross-functional teams
  • Flexibility to work in a startup atmosphere
  • Excellent oral, written and interpersonal communication skills
  • Authorized to work legally in the United States

 

Additional Qualifications Desired

  • Experience with molecular biology is a plus
  • Experience with immuno-cytochemistry and western blot techniques is a plus
  • Experience with autophagy pathways is a plus
  • Experience with optical microscopy is a plus
  • Experience with high-throughput screening is a plus
  • Experience in electrophysiology is a plus
  • Experience in a biomedical research and industry setting is a plus

Please send resume with cover letter to [email protected] .

Scientist I - Neurodegeneration

Summary of Position

QurAlis is seeking a highly motivated Scientist who is a subject matter expert in neurodegeneration and ALS to advance its cutting-edge discovery and screening efforts. The Scientist will work closely with the QurAlis scientific and management teams to perform studies in a high quality and scientifically rigorous fashion.  

Responsibilities and Duties

  • Develop and evaluate cell line, primary neuron, and iPSC-derived neuronal models of ALS/FTLD
  • Validate genetic and small molecule targets in multiple cell-based models
  • Design and execute in vitro studies to demonstrate compound pharmacodynamics and support development of early drug candidates and lead molecules
  • Perform the full spectrum of laboratory activities including experimental design, assay development, and execution.
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and management
  • Actively and intellectually contribute to group discussions on assays, targets, and project strategy, including routine presentations
  • Other duties as assigned

Minimum Qualifications Required

  • Requires a PhD in neuroscience, or related field with 0-2 years of postdoctoral training or MS with 5-7 years of experience in a pharma industry setting
  • Broad understanding in disease mechanisms particularly in the areas of ALS/FTD, and neurodegeneration in general
  • Strong laboratory skills, including molecular biology, biochemistry, high content microscopy and cell-based assays
  • Assay development experience in a biotechnology or pharmaceutical setting is preferred
  • Experience with modeling disease processes in mammalian cells in vitro to evaluate small molecule activity using imaging, reporter, viability, or other endpoints is preferred
  • Experience with pluripotent stem cells and differentiation protocols is preferred
  • Strong work ethic and excellent oral/written communication skills are essential
  • Proven track-record of scientific achievement
  • Experience in electrophysiology is a plus
  • Experience with mechanisms of protein homeostasis is a plus
  • Authorized to work legally in the United States

Please send resume with cover letter to [email protected] 

JOIN US IN THE FIGHT AGAINST ALS

If you or a loved one is battling ALS and you want to be informed about our progress or programs, we want to hear from you. Fill out the form below today and we will get back to you as quickly as possible.

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